NAD+

Nicotinamide adenine dinucleotide is supplied here as the coenzyme rather than as a precursor such as NR or NMN. It sits at the centre of cellular redox chemistry, and separately serves as a consumed substrate for three enzyme families — sirtuins, PARPs and CD38 — which is why NAD+ availability, rather than any single enzyme, is often the variable of interest in ageing and metabolic work.

Research context

• Sirtuin activity and NAD+-dependent deacetylation
• PARP activation and DNA damage response
• CD38 consumption and NAD+ pool depletion
• Mitochondrial redox state and electron transport

Working notes

NAD+ is hygroscopic and degrades in alkaline solution. Prepare fresh and keep the pH near neutral.

Allow the vial to reach room temperature before opening. Reconstitute with bacteriostatic water introduced slowly against the vial wall — do not inject directly onto the lyophilized cake and do not shake.

• Store lyophilized at −20 °C, protected from light.
• Store reconstituted solution at 2–8 °C and use within the study window.
• Avoid repeated freeze–thaw cycles.
• Handle under standard laboratory practice with appropriate PPE.

Orders are dispatched same-day when placed before 14:00 local time. Compounds ship lyophilized and are shelf-stable in transit; packaging is discreet and tamper-evident with tracking on every order.

A lot-specific Certificate of Analysis is issued for every batch and is available from the lab results library.